So how does the manga tie into the game?
I was wondering if the first light novel was applicable with DMC3?
As in does the prequel seem like if it take place before DMC3 not taking the manga into consideration.
I know old post, but I should address that.Not really. In the Novel, Vergil (or rather Gilver) is already a servant of Mundus and tries his best to summon him to our world. So if the novel was canon, then it should be after DMC3. However in the novel we also see how Dante gets Ebony & Ivory, and how the idea of opening his own shop comes into his mind. In DMC3 he already has both so by that logic DMC3 should be after the novel.
Therefore these two can't really co-exist.